Anna Louisa Supplee was born Apr 12, 1849, in Philadelphia, the youngest of three children of Andrew Hooven Supplee and Mary Jane Long. Her brother James died a young man, and her second brother died at birth.
Her mother died in 1854, her father in 1858, leaving her an orphan at the age of eight years. After her father died, she lived with her uncle, Rev. Enoch Hooven Supplee.
She was married to Albert Cadwallader in Germantown, PA, on October 20, 1868. The couple had eight children: Gertrude, Austin, Seth, Andrew, Mary, Katherine, Bertha, and James.
Anna died on Sep 15, 1905, at the home of her son, Seth Iredell Cadwallader, M.D., in Kinzua, McKean County, PA and is buried in the Milton Cemetery.